目的:探讨复方中药散结明目片对玻璃体积血兔玻璃体及视网膜匀浆中IL-6含量、积血吸收及增殖膜形成的抑制作用。方法:兔自体血造成玻璃体积血模型,设空白组、模型组、和血明目片组、散结明目片高、中、低剂量组,6wk后B超观察积血及增殖膜情况,用ELISA法检测各组玻璃体及视网膜中IL-6含量。结果:B超示散结明目片高、中剂量组积血消散明显优于低剂量组及和血明目片组,未形成增殖膜。散结明目片各剂量组及和血明目片组兔玻璃体及视网膜匀浆中IL-6含量较空白组明显升高,差异有统计学意义(P<0.05),较模型组含量降低,差异有统计学意义(P<0.05)。散结明目片高、中剂量组IL-6含量明显低于低剂量组及和血明目片组,差异有统计学意义(P<0.05),与和血明目片组及模型组相比,散结明目片高、中剂量组对机化条索及增殖膜有不同程度的抑制,差异有统计学意义(P<0.05)。结论:复方中药散结明目片能促进积血吸收,抑制机化条索及增殖膜的形成。

AIM:To investigate the effect of Sanjiemingmu tablet(SJMMT)on inhibiting proliferative vitreoretinopathy(PVR) by testing the contents of interleukin-6(IL-6) in vitreous body and retinal homogenate of modeling rabbits eyes with vitreous hemorrhage and observing hematocele and proliferative membrane.·METHODS:The models of vitreous hemorrhage were induced with autoblood in rabbits eyes and divided into blank control group,model group,positive control group treated with hexuemingmu tablet(HXMMT),and the high,medium,low-dose groups of SJMMT.Hematocele and proliferative membrane was observed by B-scan and the concentration of IL-6 in the vitreous and retinal homo-genate was examined after 6 weeks.·RESULTS:B-scan showed the hematocele absorbing of SJMMT high and medium-dose groups was better than SJMMT low-dose group and HXMMPT group.No proliferative membrane formed.Compared with blank control group,HXMMT group and the high,medium,low-dose groups of SJMMT showed significant difference(P<0.05).Compared with the model group,HXMMT group and the high,medium,low-dose groups of SJMMT showed significant difference(P<0.05).The high and medium-dose groups of SJMMT showes significant diffe-rence with the low-dose group and HXMMT group (P<0.05).·CONCLUSION:SJMMT can accelerate hematocele absor-bing,inhibit organizing trabs and proliferative membrane.

R285.5