目的:测定春季角结膜炎患者和一级亲属中相对其他过敏的患病率。方法:本前瞻性研究自1999-04/2008-03 9a间在520名春季角结膜炎的患者中进行。所有的年龄、性别、春季角结膜炎类型、其他伴随患者和/或其亲属的超敏反应的各种类别的信息记录在问卷调查表并用统计学分析。结果:520名患者中,男369例(71.0%),女151例(29·0%)。患者的平均年龄为15.3岁(6 ~30岁)。242例(46.5%)曾在自己或其一级亲属中有春季角结膜炎或其他类型超敏反应的历史。在这些阳性病史病例中,68例(28.1%)有过敏性皮炎,51例(21.1%)(其亲属)春季结膜炎,46例(19.0%)哮喘,29例(12.0%)过敏性鼻窦炎,24例(10.0%)药物过敏,14例(5.8%)特应性皮炎,6例(2.5%)过敏性鼻炎,4例(1.6%)有花粉热的历史。结论:不少春季角结膜炎患者和/或其亲属有其他由IgE介导的过敏或其他类型。哮喘、药物引起的过敏和其他过敏在这些患者中普遍。患者的亲属中春季角结膜炎比率高,因此它可能是由于疾病的遗传起源。

AIM: To determine the prevalence of other allergies in patients with vernal keratoconjunctivitis(VKC) and their first-degree relatives. METHODS: This prospective study was done on 520 patients with VKC over a 9-year period from April 1999 to March 2008. All information such as age, sex, types of vernal and various types of other accompanying hypersen-sitivities in patients and/or their relatives were recorded on questionnaires and analyzed statistically. RESULTS: Among 520 patients, 369 (71.0%) were male and 151 (29.0%) were female. The mean age of patients was 15.3 years (6-30 years). 242 cases (46.5%) had history of vernal or other types of hypersensitivities in themselves or their first-degree relatives. Among these positive history cases ,68 patients (28.1%) had allergic dermatitis,51 cases (21.1%)vernal conjunctivitis (in their relatives),46 cases (19.0%)asthma, 29 cases (12.0%) allergic sinusitis, 24 cases (10.0%)drugs hypersensitivity, 14 cases (5.8%) atopic dermatitis, 6 cases (2.5%) allergic rhinitis and 4 cases (1.6%) had hay fever history. CONCLUSION: Many patients with VKC have other IgE-mediated or other types of hypersensitivity in him/her self and/or their relatives. Asthma, drug induced allergy and other hypersensitivities are common in these patients. The rate of vernal in relatives of patients was high, so it may be due to genetic origin of the disease.

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