患者,女,32岁,被诊断为纵隔未分化大细胞非霍奇金淋巴瘤,化疗后3a出现双眼悬浮物和右眼视力下降。眼科检查发现带有多发深在的左眼脉络膜病变的双侧全葡萄膜炎。眼窝电脑断层扫描显示两侧球后视神经部分加强和大块的视神经鞘。该患者接受眼窝受累区域放射治疗,累积剂量为30戈瑞。放射治疗8mo后,发展为黄斑部视网膜色素上皮脱离和右侧颞上和鼻下区眼底的深脉络膜视网膜变性。在脉络膜视网膜变性区边缘有玻璃体视网膜牵引迹象,从而路障激光在受累眼睛进行。双眼视力仍然6/6。视网膜色素上皮脱离可能是放射治疗非霍奇金淋巴瘤眼内转移时的并发症。至关重要的是提醒了眼科医生这个罕见的并发症。

A 32-year-old lady, diagnosed with anaplastic large cell non-Hodgkin’s lymphoma of the mediastinum, presented with bilateral floaters and reduced right eye vision 3 years post chemotherapy. Ophthalmic examination revealed bilateral panuveitis with multiple deep seated choroidal lesions in the left eye. Computed tomography scanning of the orbit showed enhancing and bulky optic nerve sheath at the retrobulbar part of both optic nerves. The patient was treated with involved field radiation therapy of the orbit, with cumulative dose of 30Gy. Eight months post radiation therapy, she developed retinal pigment epithelial detachment at the macula and deep chorioretinal degeneration at superotemporal and inferonasal regions of the right fundus. There was evidence of vitreoretinal traction at the margin of chorioretinal degeneration areas, thus barricade lasers were performed in the affected eye. Her visual acuity remains 6/6 in both eyes. Retinal pigment epithelial detachment is a possible complication of radiation therapy in non-Hodgkin’s lymphoma with intraocular metastasis. It is essential to alert the managing ophthalmologists about this rare complication.