目的:探讨影响近视患者角膜中央厚度的相关因素。方法:对近视眼患者2027例4002眼用超声角膜测厚仪、电脑验光仪、非接触眼压计、A超和角膜地形图分别测量角膜中央厚度、屈光度、眼压和内皮细胞计数等数据,并统计是否有配戴角膜接触镜史。对所得数据结果进行统计学分析。结果:有无配戴角膜接触镜史与角膜中央厚度为负相关(t=-4.475,P=0.000)。角膜中央厚度与眼压呈正相关(r=2.856,P=0.000);与屈光度数为负相关(r=-0.662,P=0.000),与内皮细胞计数无相关(r=0.003,P=0.065),建立多元回归方程:y=-0.626X1-0.662X2+0.003X3+2.856X4+500.606。结论:影响近视眼患者角膜中央厚度的主要因素是:配戴角膜接触镜史、屈光度数和眼压。

AIM: To investigate the factors correlated with central corneal thickness(CCT) in patients with myopia. METHODS: A total of 2 027 patients 4 002 eyes of myopia were examined. CCT was measured by ultrasound corneal pachymeter. Refraction was measured by automatic refractor. Intraocular pressure (IOP) was mea-sured by non-contact tonometer. Corneal endothelia was measured by corneal topography. History of wearing soft contact lens and other factors were also analyzed. RESULTS: A negative correlation was found between CCT and history of wearing soft contact lens (t=- 4.475, P=0.000).The correlation between IOP and CCT was significant (r=2.856, P=0.000), and. CCT was nega-tively correlated with refraction (r=- 0.662, P=0.000). No signifi-cant correlation was found between CCT and corneal endothelia. CONCLUSION: The CCT in patients of myopia was correlated with history of wearing soft contact lens,refraction and IOP.

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