目的:通过对那他霉素和氟康唑治疗真菌性角膜溃疡的对照研究,探讨那他霉素在真菌性角膜溃疡愈合中的治疗作用。方法:对84例确诊真菌性角膜溃疡患者随机分为甲、乙两组,每组42例,分别用那他霉素眼液及氟康唑眼液进行治疗。结果:那他霉素组治愈21例,有效34例,无效8例,有效率81%;氟康唑组治愈11例,有效29例,无效13例,有效率69%;两组有效率比较,差异无统计学意义(χ2=1.587,P>0.05);两组治愈率比较,差异有统计学意义(χ2=5.048,P<0.05),那他霉素组治愈率(50%)明显高于氟康唑组(26%);那他霉素组有效治疗时间(16.7±7.68d),明显低于氟康唑组(28.6±7.3d),两组差异显著,有统计学意义(t=7.94,P<0.01)。结论:那他霉素对真菌性角膜溃疡具有较好的治疗作用,优于氟康唑。值得临床推广使用。

AIM: To evaluate the efficacy of natamyc in curing fungal corneal ulcer by a case-control study of natamyc and fluconazole. METHODS: Eighty-four cases with fungal corneal ulcer were divided into two groups with 42 cases in each group. Natamyc and fluconazole were used for each group respectively. RESULTS: Twenty-one cases were cured, 34 cases were effectively and 8 cases were ineffective, the effective rate was 81% in natamyc group.In fluconazole group, the corresponding number of cases was 11,29,13 respectively, and the effectively and ineffectively,effective rate was 69%. There was no significant difference between the two groups in effective rate (χ2=1.587,P>0.05);there was a significant difference between the two groups in cure rate (χ2=5.048,P<0.05),and also a significant difference between the two groups in average period of therapy which was 16.7±7.68 days in natamyc group and 28.6±7.3 days in fluconazole group (t=7.94, P<0.01). CONCLUSION: Natamyc is more effective than fluconazole in treatment of fungal corneal ulcer, which can be generalized in clinic.

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