棘阿米巴角膜炎(acanthamoeba keratitis,AK)是一种以环形浸润和角膜神经炎为典型临床表现的严重性眼病。它的发病机制主要包括棘阿米巴对角膜上皮的黏附,滋养体介导的病理效应以及释放多种蛋白酶破坏角膜基质层组织。由于棘阿米巴对神经细胞的强烈趋化效应,可引起相应的角膜神经炎。目前,AK的发病机制尚不明确,但随着研究的深入可以为眼科医师提供更有效的诊断和治疗措施。

·Acanthamoeba keratitis is a sight-threatening infection,which is characterized by ring-like stromal infiltration and keratonueuritis.The pathophysiology cascade of this infection begins when the trophozoites bind to the corneal epithelium.Following processes include trophozoite-mediated cytopathic effects and the productions of several pathogenic proteases that degrade collagenous stroma.Because of the predilection of acanthamoeba for respond-ing chemotactically to nural cell,it can produce what appears to be keratoneuritis.However the pathophysio-logy of acanthamoeba keratitis is still unclear,targeting pathophysiology could lead to the development of the diagnosis and treatment of this disease.·

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