谷氨酸受体可分为促离子型谷氨酸受体(iGluR)和促代谢型谷氨酸受体(mGluR),促离子型受体可分为NMDA型受体和非NMDA型受体。促代谢型受体包括mGluR1～mGluR88种。其在中枢神经系统分布广泛,与突触的可塑性、谷氨酸的兴奋毒性、神经元的损伤与保护、长时程增强(LTP)和长时程抑制(LTD)、学习和记忆等多种功能密切相关。在弱视方面研究较多的是NMDA受体,其数量、活性在弱视组与正常组相比都有显著性差异。

·Glutamate receptor can be divided into metabotropic receptor(mGluR)and ionotropic receptor(iGluR).The iGluR includes NMDA receptor and non-NMDA receptor.mGluR includes mGluR1 to mGluR8.They are mainly distributed in the central nervous system(CNS).They have an important role in synaptic plasticity,exitotoxicity of glutamate,protection and damage of neuron,long-term potentiation(LTP)and long-term depression(LTD),study and memory.The NMDA receptor is studied considerably in amblyopia.There are significant differences in quantity and activity between contrast group and amblyopia group.·

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