目的:研究熊胆引流液对糖尿病大鼠视网膜氧化损伤的保护作用。方法:STZ诱导糖尿病SD大鼠模型,治疗组给予引流熊胆液灌胃,观察血糖、体质量变化和24wk视网膜组织SOD和MDA水平及超微结构改变。结果:糖尿病大鼠视网膜SOD水平下降,MDA水平上升,病理改变主要是三级神经元和神经胶质细胞的线粒体病变和细胞的变性、凋亡。引流熊胆液组与糖尿病模型组对比体重和血糖没有改变,而视网膜SOD水平升高,MDA水平降低,超微结构病变明显减轻。结论:引流熊胆液可以下调高血糖视网膜的氧化应激水平,减轻线粒体的病理改变,阻止神经细胞凋亡。

AIM:To study the therapic effect of drainage Fel Ursi (DFU) on retinal oxidative damage in strepfozocin-induced diabetic rats.·METHODS: The changes of body weight, blood glucose, retinal ultrastructure, SOD and MDA among the normal SD rats,diabetic rats and diabetic rats therapied by DFU were compared. ·RESULTS: There were mitochondrion changes, cell degeneration and apoptosis of retinal neurones and neuroglia cells in the diabetic rats retina. Compared with the control group, the SOD decreased significantly (P<0.05), the MDA increased significantly(P<0.05). However, the body weight and blood glucose had the same changes between the therapic group and diabetic rats group. ·CONCLUSION: DFU can relieve the retinal cells mito-chondrion pathological changes, prevent the cells apopto-sis, block up the process of the pathological changes of the retinal blood vessel.

R587.2

国家自然科学基金重点资助项目(No.60827002);中国福建省卫生厅中医药科研重点课题资助项目(No.wzzyb0905);中国卫生部科研课题资助项目(No.WKJ2005-2-013)~~