目的:探讨超声乳化白内障吸除术对泪膜及泪液分泌变化的影响。方法:检索PubMed,Web of knowledge、中华期刊网和中国生物医学文献数据库,辅以Google网络检索和手工检索,筛选得到6篇2000-01/2009-08发表的关于超声乳化白内障吸除术对泪膜和泪液分泌变化影响的研究,以手术前与术后3mo泪膜破裂时间(break-up time,BUT)和基础泪液分泌试验(SchirmerⅠtest,SⅠt)均数差值(relativedifference,RD)为效应指标,应用随机效应模型对入选文献的数据资料进行Meta分析。结果:术后3mo时BUT仍低于手术前水平,差异有统计学意义[RD的加权平均估计值为1.34,95%可信区间为(0.40,2.30),P=0.01]。术后3mo时SⅠt值略低于手术前水平,但差异无统计学意义[RD的加权平均估计值为0.80,95%可信区间为(-0.14,1.75),P=0.10]。结论:术后3mo时,超声乳化白内障吸除术后泪膜稳定性仍降低,但基础泪液分泌量已基本恢复至术前水平。

·AIM:To evaluate changes of tear film and tear secretion after phacoemulsification for cataract.·METHODS:Six articles published from January 2000 to August 2009 were retrieved through the following databases:PubMed,Web of knowledge,CNKI,Chinese Bio-medicine Database along with Google web search and manual retrieval.Relative difference(RD)between preoperative and 3-month-postoperative tear film break-up time(BUT)and Schirmer Ⅰ test(S Ⅰ t)were set as the effect indexes.The data of these articles were evaluated with Meta-analysis by random model.·RESULTS:At 3-month-postoperative time,the BUT value was significantly lower than the preoperative value[weighted average value of RD is 1.34 with 95% confidence interval(CI)in(0.40,2.30),P=0.01],but the SⅠt value did not differ from preoperative value significantly[weighted aver-age value of RD is 0.80,95% CI is(-0.14,1.75),P=0.10].·CONCLUSION:At 3-month-postoperative time,the stability of tear film has not recovered yet,but the tear secretion has recovered to preoperative level in eyes underwent phacoemulsification surgery for cataract.·

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