目的:探讨在经鼻内窥镜泪囊鼻腔吻合术中应用丝裂霉素C治疗慢性泪囊炎的临床疗效。方法:将65例慢性泪囊炎患者分为治疗组和对照组;治疗组在经鼻内窥镜泪囊鼻腔吻合术中局部应用0.4mg/mL丝裂霉素C,对照组行传统泪囊鼻腔吻合术;术后随访12mo,观察患者泪道通畅情况,鼻内窥镜下测量造瘘口面积,检查鼻腔结构恢复情况。结果:治疗组35例39眼,治愈38眼,治愈率97%;对照组30例34眼,治愈26眼,治愈率76%,两组之间的差异有统计学意义(P<0.05)。结论:在经鼻内窥镜泪囊鼻腔吻合术中局部应用丝裂霉素C治疗慢性泪囊炎,组织损伤小、面部不留瘢痕,能有效减少术后吻合口闭锁,提高手术成功率,可作为一种简便、安全有效的治疗方式。

·AIM:To discuss the clinical effect of mitomycin C in nasal endoscopic dacryocystorhinostomy for curing chronic dacryocystitis.·METHODS:Totally 65 patients with chronic dacryocystitis were divided into treatment group and control group;the patients in treatment group received 0.4mg/mL of mitomycin C when undergoing nasal endoscopic dacryocystorhinostomy,while the patients in control group received no medicine when undergoing traditional dacryocystorhinostomy.After 12 months follow-up the patency of lacrimal passage was observed,and the area of ostomy with nasal endoscope and mycteric recovery was examined.·RESULTS:Of all 39 eyes 35 patients in treatment group,38 eyes were cured,the cure rate was 97%;of all 34 eyes 30 patients in control group,26 eyes were cured,the cure rate was 76%;a significant difference was found in cure rate between two groups(P<0.05).·CONCLUSION:The application of mitomycin C in nasal endoscopic dacryocystorhinostomy is a simple,safe and effective way to treat the chronic dacryocystitis,because it possesses the advantages of small injuries of tissue,few scar of face,small atresia of ostomy and high successful rate.·

R779.6