目的:比较国产散瞳药卓比安与进口散瞳药美多丽在老年性白内障超声乳化联合人工晶状体植入术前及术中的散瞳效果。方法:患者200例术前1d随机分为两组,每组各100例:试验组为卓比安组和对照组美多丽组。点眼前测量两组双侧瞳孔大小并记录,共3次点药,每隔5min1次,点药结束后15,20,25min观察并记录瞳孔直径大小,及瞳孔开始回缩时间。卓比安组和美多丽组于术前1h点药3次,每次间隔5min,白内障超声乳化术中,观察并记录术前,注入黏弹剂后,超声乳化完成后瞳孔直径及有效超声乳化时间,并进行统计学比较。结果:卓比安组与美多丽组术前1d间隔5min3次点药,于点药结束后20min左右均能达到最大瞳孔直径,且两组最大瞳孔直径无统计学差异;卓比安组与美多丽组瞳孔开始回缩时间(h)分别为2.49±0.75h与2.85±0.74h,且两者有统计学差异。超声乳化过程中国产散瞳药卓比安与美多丽维持散瞳效果相同。结论:国产散瞳药卓比安组与进口散瞳药美多丽组相比术前与术中散瞳效果无统计学差异,但术前瞳孔维持最大直径时间(h)卓比安组要比美多丽时间短,且两者有统计学差异。

AIM:To observe the effects of domestic mydriatic before and during phacoemulsification. ·METHODS:The selected 200 patients were divided equally into the experiment group (zhoubian group) and the control group(Mydrin-P groups) randomly. The pupil diameter 15,20,25 minutes after three times dropping mydriatics was recorded respectively and the time of pupil started to recession one day before operation. After dropping mydriatic one hour before operation,the pupil diameter was recorded before operation,after sodium hyaluronate injected and at the end of operation. The entire operation time and the effective phaco-time was recorded. Then the data obtained from 2 groups were compared. ·RESULTS:The max-diameter of pupils in the experiment group and the control group were (7.45±0.72) mm and (7.22±0.97) mm respectively 20 minutes after dropping the mydriatic,there was no difference between the 2 groups.But the recession time in the experiment group and the control group were (2.85±0.74) hours and (2.49±0.75) hours,the difference between two groups was significant.The maintenance effect of mydriasis during phacoemulsification also has no difference between two groups regarding to the same lens nucleus hardness. ·CONCLUSION:The domestic mydriatic zhuobian has the same effect of mydriasis preoperation and during operation,but in zhoubian group the recession time was shorter than Mydrin-P group,and the difference was significant.

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