目的:探讨2型糖尿病并发视网膜病变(diabetic retinopathy,DR)患者血清脂联素和超敏C-反应蛋白(high sensitivity C-reactive protein,hs-CRP)浓度的变化。方法:病例对照研究。采用酶联免疫吸附法和速率散射比浊法检测49例非糖尿病视网膜病变(NDR)的糖尿病患者,46例非增生性糖尿病视网膜病变(NPDR)组患者,41例增生性糖尿病视网膜病变(PDR)组患者以及45例对照组受检者血清脂联素和超敏C-反应蛋白(hs-CRP)浓度的变化,采用单因素设计的定量资料的方差分析,多个均数之间两两比较采用q检验,相关分析采用直线相关分析。结果:NDR组患者血清脂联素浓度8.76±3.61mg/L,hs-CRP浓度3.12±1.24mg/L;NPDR组患者血清脂联素浓度6.22±2.53mg/L,hs-CRP浓度4.89±1.66mg/L;PDR组患者血清脂联素浓度3.98±1.86mg/L,hs-CRP浓度6.95±2.59mg/L;对照组血清脂联素浓度13.55±5.87mg/L,hs-CRP浓度2.01±0.85mg/L。正常对照组与NDR组、NDR组与NPDR组、NPDR组与PDR组的血清脂联素比较,差异有统计学意义(q=5.4401,P=0.000;q=3.1535,P=0.002;q=4.8756,P=0.000)。正常对照组与NDR组、NDR组与NPDR组、NPDR组与PDR组血清hs-CRP浓度比较,差异具有统计学意义(q=2.4367,P=0.0017;q=2.0572,P=0.003;q=2.6184,P=0.001)。DR患者血清hs-CRP与血清脂联素水平呈负相关(r=-0.643,P<0.01)。结论:DR患者血清脂联素浓度水平与血清hs-CRP浓度水平存在显著负相关,血清脂联素浓度水平下降,伴随着血清hs-CRP浓度水平的升高,且与糖尿病视网膜病变的严重程度相关。

AIM:To explore the changes of the concentration of serum adiponectin(APN) and high sensitivity C-reactive protein (hs-CRP) in type 2 diabetes mellitus patients with diabetic retinopathy (DR). ·METHODS:The concentration of serum APN and hs-CRP in 49 no-DR(NDR) patients were determined by ELISA and ratenephelometry and compared with those in 46 no-PDR (NPDR) patients,41 proliferative diabetic retinopathy(PDR) patients and 45 controls. Data were evaluated using analysis of SPSS version 11.0. Results were expressed as means standard deviation of the mean. Statistical comparisons were performed by One-way analysis of variance and the means compared each other using q test. ·RESULTS:The serum APN and hs-CRP in NDR patients were 8.76±3.61mg/L,3.12±1.24mg/L; in NPDR patients were 6.22±2.53mg/L,4.89±1.66mg/L; in PDR patients were 3.98±1.86mg/L,6.95±2.59mg/L and in controls were 13.55±5.87mg/L,2.01±0.85mg/L. There were significant differences in serum APN and hs-CRP between controls and NDR patients,NDR and NPDR patients NPDR and PDR patients (q=5.4401,P=0.000; q=2.4367,P=0.0017. q=3.1535,P=0.002; q=2.0572,P=0.003. q=4.8756,P=0.000; q=2.6184,P=0.001). There was significant negative correlation between serum APN and hs-CRP in DR patients(r=-0.643,P<0.01). ·CONCLUSION:There is significant negative correlation between serum APN and hs-CRP in DR patients. The serum APN concentration decreases while the serum hs-CRP concentration increases,which may contribute to the development of DR.

中国四川省科技厅科技支撑资助项目(No.2008sz0201);中国四川省绵阳市应用技术研究与开发资金资助项目(No.08s002)~~