紫外光核黄素角膜交联术(corneal collagen cross-linking,CCL)是一种二十一世纪初应用于临床的最新的角膜成形技术。以核黄素作为光敏剂应用370nm紫外线对角膜进行局部照射,刺激胶原纤维交联,增加角膜硬度。该技术已经在临床崭露头角,有望成为人们比较熟悉的角膜成型技术如传导性角膜成形术和角膜基质环植入术的辅助治疗手段。这些被称为角膜成形学的治疗或手术技术,可望开辟一个新的领域,治疗以往无法治疗的某些角膜疾病。利用CCL,眼科医生可重塑角膜结构,而不需使用如穿透性角膜移植术或板层角膜移植术等创伤性技术。用这种方法代替角膜基质环植入术,或与之相结合,可显著提高圆锥角膜的治疗效果。经过几年的苦心研究,CCL的技术方法得到了改进,治疗范围也有所扩大。不仅用来治疗进展性圆锥角膜,同时也为难治性角膜溃疡、角膜变性、术后角膜扩张病等角膜疾病的治疗带来希望。

Corneal collagen cross-linking( CCL) is the latest corneal shape technology in clinical application in 21 century. Riboflavin,a photosensitizer,can be applied to local irradiation of the cornea by 370nm ultraviolet and it can stimulate collagen cross-linking,and increase corneal rigidity. The technology is expected to become more familiar with the corneal molding techniques such as conductive keratoplasty and corneal ring implantation for secondary treatment in clinic. These corneal molding surgeries are expected to open up a new field,and treated with new corneal disease. Ophthalmologists can reshape the corneal structure without penetrating keratoplasty or lamellar keratoplasty and other invasive techniques by CCL. Instead of corneal ring implantation,it can improve significantly treatment effect of keratoconus. Technical methods with CCL has been improved,and the treatment range has also increased. Besides progressive kera-toconus,the refractory corneal ulcer,corneal degenera-tion,corneal expansion diseases were all applied.

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