目的:探讨瘢痕性天疱疮临床特点,为临床诊治提供帮助。方法:回顾性分析2002-01/2008-01我科诊治的35例瘢痕性天疱疮临床特点。结果:瘢痕性天疱疮平均发病年龄为62.4岁,男女性别比为20∶15,病史平均3.3a,51.43%以口腔黏膜病变首发,31.43%以眼部病变首发,眼睑内翻倒睫/慢性结膜炎和干眼/角膜病变为5/4/2,17.14%以其它黏膜病变首发。经过治疗,71.43%(25/35)患者症状消失或缓解超过3mo,14.29%(5/35)患者症状反复或无明显缓解,14.29%(5/35)患者中途退出治疗。治疗过程中37.14%(13/35)患者出现全身其它异常,其中6例出现肝功能异常,2例终止治疗,肾功能异常2例,1例终止治疗,血液系统异常3例,1例退出治疗,心肌梗塞1例,退出治疗,明显血压升高1例。结论:瘢痕性天疱疮是一种慢性病,多发于老年人,男性稍多于女性,眼组织经常受累,多表现为干眼症、睑球粘连和内翻倒睫。瘢痕性天疱疮治疗复杂,经常需要多学科协作。

AIM:To explore the clinical characteristics of ocular cicatricial pemphigoid,and provide assistance in clinical diagnosis and therapy. ·METHODS:The data of 35 cases of ocular cicatricial pemphcgoid from January,2002 to January,2008 was retrospectively analyzed. ·RESULTS:The average age of ocular cicatricial pemphigoid was 62.4 years,and the rate of male and female gender was 20/15. The average history was 3.3 years. The oral mucosa was firstly invaded in 51.43% patients,ocular mucosa in 31.43% ones,and other mucosa in 17.14% ones. In eye-involved patients,the rate of eyelid entropium and trichiasis,dry eye and chronic conjunctivitis,and corneopathy was 5/4/2. After treatment,71.43%(25/35) cases were cured,while 14.29% (5/35)cases were not cured,and 14.29%(5/35)cases did not accomplished the regimen. In the course of treatment,the complications were found in 37.14% (13/35)cases,and among these,abnormal liver function was found in 6 cases and 2 cases withdrew from treatment,abnormal kidney function in 2 cases and 1 case discontinued the protocal,abnormal blood system in 3 cases and 1 case quitted the regimen,myocardial infarction in 1 case who gave up the treatment,and apparent blood hypertension in 1 case. ·CONCLUSION:Cicatricial pemphigoid is a chronic ailment and often involved in the elderly. Male patients are more than female ones,and ocular tissue is often involved. Dry eye disease,symblepharon,entropion and trichisis are all its manifestations. The treatment of cicatricial pemphigoid is complicated,and multidisciplinary collaboration is required.

R758.6