目的:研究细胞因子VEGF,Ang-1对大鼠脉络膜新生血管的形成、分化以及成熟过程的影响及机制。方法:采用激光光凝诱导建立大鼠CNV动物模型后,分别在不同时期玻璃体腔注射VEGF,Ang-1,通过其眼底荧光造影与病理切片的变化观察上述因子的作用。结果:血管生成素-1组比对照组晚期渗漏明显减少,VEGF组较对照组晚期渗漏明显增加;组织病理切片显示实验组瘢痕形成,VEGF组和对照组可见肉芽组织。结论:血管生成素-1能有效抑制脉络膜新生血管的生成,促进新生的脉络膜新生血管成熟,促进瘢痕形成。

AIM:To explore the effect and mechanism of VEGF and Ang-1 on differentiation and maturation of choroidal neovascluarization. METHODS:Mice of CNV model were received intravitreous injection with VEGF or Ang-1,the FFA images and pathological section were analyzed to detect the effects of factor Ang-1 or VEGF. RESULTS:In CNV model mice Ang-1 group was found less later period leakage than the control group,while in VEGF group is more than the control group.The scar was found in pathological tissue section of Ang-1 group,and granulation tissue was found in VEGF and control group. CONCLUSION:Ang-1 can suppress the formation and maturation of CNV and improve the scar formation.

中国山东省自然科学基金资助项目(No.Y2006C101)~~