目的:观察卵磷脂络合碘联合氩激光治疗中心性浆液性脉络膜视网膜病变(central serous chorioretinopathy,CSC)的疗效。方法:将60例67眼眼底渗漏点距黄斑中心凹250μm以外的中心性浆液性脉络膜视网膜病变患者,随机分为两组,治疗组30例34眼,采用卵磷脂络合碘口服联合氩激光光凝眼底;对照组30例33眼仅采用氩激光光凝眼底,观察比较治疗后患者的眼底、视力、激光治疗次数、治愈时间、疗效及复发率的不同。结果:治疗组治疗后眼底造影荧光素渗漏吸收情况快于对照组,比较差异有统计学意义(P<0.05);治疗后治疗组、对照组的视力均有明显提高(P<0.01),但治疗组治疗后的视力明显高于对照组治疗后(P<0.01);治疗组激光治疗次数少于对照组,比较差异有统计学意义(P<0.05);治疗组治愈时间短于对照组,比较差异有统计学意义(P<0.05);治疗组疗效优于对照组,比较差异有统计学意义(P<0.05);且治疗组复发率低于对照组,比较差异有统计学意义(P<0.05)。结论:卵磷脂络合碘联合氩激光是治疗眼底渗漏点距黄斑中心凹250μm以外中心性浆液性脉络膜视网膜病变的有效方法,值得推广。

AIM:To observe effects of Jolethin combined with argon laser for central serous chorioretinopathy(CSC). ·METHODS:Totally 60 patients 67 eyes with CSC (leakage zone:extrafoveal≥ 250μm) were devided into two groups randomly,and the treatment group included 30 patients 34 eyes who were treated by Jolethin through oral way and photocoagulation with argon laser,while the control group included 30 patients 33 eyes who were only treated by photocoagulation with argon laser. The difference of optic fundi,visual acuity,frequency of laser treatment,healing time,therapeutic effect and the recurrence rate were observed and compared after treatment. ·RESULTS:After treatment,the absorption of leakage by fundus fluorescein angiography was faster in the treatment group than that in the control group,and the difference was statistically significant (P<0.05); The visual acuity in both groups were significantly improved (P<0.01);However,the visual acuity in the treatment group was significantly higher than that of control group (P<0.01). The number of laser treatment was in the treatment group less than that in the control group,the difference was statistically significant (P<0.05); The treatment group were cured in a short time group,the difference was statistically significant (P<0.05); The therapeutic effect of the two groups had a significant difference (P<0.05);the recurrence rate in the treatment group was significantly lower than that in control group (P<0.05). ·CONCLUSION:It is effective to treat CSC (leakage zone:extrafoveal≥ 250μm) by Jolethin combined with argon laser.

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