目的:观察显微镜下复发性翼状胬肉患者自体角膜缘干细胞移植术与羊膜移植术后疗效比较。方法:将复发性翼状胬肉患者90例96眼随机分为A,B两组,A组40例42眼行胬肉切除联合自体角膜缘干细胞移植;B组50例54眼行胬肉切除联合羊膜移植,观察术后患者自觉症状,角膜愈合情况,角膜缘处结膜组织愈合情况,新生血管及2a内胬肉组织增生情况。结果:角膜缘干细胞移植组治愈39眼(93%),复发3眼(7%);羊膜移植组治愈48眼(89%),复发6眼(11%),两组比较差异无统计学意义(χ2=0.0456,P>0.05)。角膜创面平均愈合时间角膜缘干细胞移植组为(4.12±1.08)d,羊膜移植组(7.38±1.12)d,两组比较有显著性差异(t=4.307,P<0.05)。结论:角膜缘干细胞移植与羊膜移植均效果良好,复发率低,但角膜缘干细胞移植术具有角膜创面上皮愈合快,患者不适感随之消失较快的优点,值得临床推广。

AIM:To compare the curative effect of corneal limbal stem cell transplantation and amniotic membrane transpl-antation under the microscope for recurrent pterygium.METHODS:Ninety patients 96 eyes with recurrent pterygium were randomly divided into A,B groups.A group 40 patients 42 eyes underwent pterygium excision combined with autologous corneal limbal stem cell transplantation.B group,50 patients 54 eyes,underwent pterygium excision with amniotic membrane transplantation.Postoperative symptoms,corneal healing,conjunctival tissue healing,neovascularization and pterygial proliferation in 2 years were observed.RESULTS:In A group 39 eyes(93%) were cured,3 eyes(7%) recurred;of B group 48 eyes(89%) cured,6 eyes(11%) recurred in 96 eyes,the difference was not significant(χ 2=0.0456,P>0.05).The average time of corneal healing was that A group was(4.12±1.08) days,B group(7.38±1.12) days respectively.There were significant differences in two groups(t=4.307,P<0.05).CONCLUSION:There are good curative effect and low recurrence rate in both groups,but A group is worthy of clinical generalization with faster corneal epithelial healing and discomfortableness disappearance.

R779.6