目的:评价拉坦噻吗滴眼液(适利加)降眼压治疗的有效性和安全性。方法:选取30例52眼原发性开角型/闭角型青光眼患者单用拉坦噻吗滴眼液,每晚1次,随访16wk,观察眼压、视野、平均视神经纤维层厚度及不良反应。结果:拉坦噻吗滴眼液能显著降低眼压(P=0.000),16wk后降眼压幅度的95%可信区间为10.31～13.92mmHg,但对视野及平均视神经纤维层厚度无改善(P>0.05),不良反应主要为眼睛轻度充血。结论:拉坦噻吗滴眼液能显著降低原发性开角型/闭角型青光眼患者的眼压,而且用药安全,依从性好。但短期随访并未发现其对视野及平均视神经纤维层厚度有改善。

AIM:To evaluate the efficacy and safty of latanoprost and timolol maleate eye drops reducing IOP.METHODS:Fifty-two eyes of 30 primary glaucoma patients were dosed with latanoprost and timolol maleate eye drops as a single therapy once daily.The observed signs included IOP,field of vision,mRNFL and complications.The follow-up duration was 16 weeks.RESULTS:Latanoprost and timolol maleate eye drops reduced IOP significantly(P=0.000),but didn’t have effects to field of vision and mRNFL.After 16 weeks,95% confidence interval of IOP reductions ranged from 10.31 to 13.92mmHg.The most complications was conjunctival congestion.CONCLUSION:Latanoprost and timolol maleate eye drops reduced IOP significantly in primary glaucoma patients and was safe and well tolerated.But the field of vision and mRNFL are not ameliorated within short-term follow-up.

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