目的:观察5-氟尿嘧啶(5-FU)治疗早期复发性翼状胬肉的临床疗效。方法:早期复发性翼状胬肉患者48例采用结膜下注射5-FU,观察结膜角膜眼压及前房反应,定期随访观察。结果:随访6～24mo,48例复发病例中,痊愈加显效30例,有效12例,6例无效。2例结膜囊缩窄,6例继续进展再次手术。12例角膜上皮点状脱落,停药48h愈合。结论:5-FU结膜下注射是治疗早期复发性翼状胬肉的一种安全、简便、有效的方法。

AIM:To investigate the clinical effect of 5-fluorouracil(5-FU) on the treatment of early recurrent pterygium.METHODS:Forty-eight case with recurrent pterygium were treated with 5-FU by subconjunctival injection.The intraocular pressure and anterior chamber reaction were observed in the regular follow-up.RESULTS:The treated patients with early recurrent pterygium were followed up for 6-24 months.Patients that were cured or with evident effect was 30 cases,effect 12 cases,invalid 6 cases.2 cases were with constriction of conjunctival sac,6 cases were performed operation again because of the disease progress.The shedding of corneal epithelial was healing 48 hours after withdrawl of drug.CONCLUSION:The subconjunctival injection of 5-FU is a useful method for the treatment of early recurrent pterygium.

R777.33