目的:了解亚临床期圆锥角膜(subclinical keratoconus,SKC)患者的高阶波前像差的表现。方法:采用病例对照研究,收集20例32眼SKC患者作为SKC组,选取同时期20例40眼近视患者作为对照组,分别测量两组的波前像差,用t检验比较两组间的总高阶像差、球差和彗差的RMS值,用χ2检验比较两组间负性球差所占的比例。结果:SKC组的总高阶像差、球差和彗差的RMS值分别为0.637±0.488μm,0.276±0.135μm,0.364±0.205μm,对照组为0.394±0.282μm,0.113±0.084μm,0.148±0.079μm,两组间的差异有统计学意义(t=2.160,2.341,3.679;P<0.05);SKC组共有19眼表现为负性球差,对照组有9眼为负性球差,两组间的差异有统计学意义(χ2=10.17,P=0.001)。结论:亚临床期圆锥角膜患者的高阶像差明显增加,波前像差检查有助于亚临床期圆锥角膜的辅助诊断。

·AIM:To investigate the manifestation of high order wavefront aberrations(HOAs)in patients with subclinical keratoconus(SKC).METHODS:It was a case-control study.In this study 20 patients(32 eyes)with SKC was in SKC group and 20 patients(40 eyes)with myopia were selected in the same period as control group.Wavefront aberrations in each eye was measured by OPD Scan ARK-10000(NIDEK,Japan).Statistical analysis was performed to compare the root mean square(RMS)of total ocular HOAs,spherical aberration and coma between 2 groups respectively by Student’s t-test.RESULTS:The RMS of total ocular HOAs,spherical aberration and coma were 0.637±0.488μm,0.276±0.135μm,0.364±0.205μm respectively in SKC group,while that in control group were 0.394±0.282μm,0.113±0.084μm,0.148±0.079μm respectively,the differences were statistically significant(t=2.160,2.341,3.679;P<0.05).Negative spherical aberration was found in 19 eyes in SKC group and 9 eyes in control group,the differences were statistically significant(χ2=10.17;P=0.001).CONCLUSION:The HOAs is significantly higher in eyes with SKC than in myopic eyes.It may be helpful for detecting SKC to measure wavefront aberrations.

R779.63