目的:评价并比较一切口和二切口超声乳化白内障吸除术联合小梁切除术治疗慢性闭角型青光眼合并白内障的疗效。方法:采用前瞻性随机对照临床试验研究,包括41例41眼具有慢性闭角型青光眼合并白内障的患者。21例行一切口超声乳化白内障吸除术联合小梁切除术,20例行二切口手术。术后观察的指标包括:术后眼内压(IOP)、抗青光眼药物使用数量、最佳矫正视力(BCVA)以及术后并发症。所有研究对象随访9mo。结果:两组研究对象术前各项指标没有差别。术后9mo,一切口组和二切口组IOP分别从术前22.7±4.9mmHg,23.7±4.7mmHg降至18.0±1.2mmHg,16.7±1.1mmHg(P<0.05)。各随访时间点两组IOP差别没有统计学意义(P>0.05)。术后9mo,两组抗青光眼药物减少和BCVA提高差异均无统计学意义(P>0.05)。两种手术方式在术后并发症方面无差异。结论:两种超声乳化白内障吸除术联合小梁切除手术方式治疗的临床疗效和术后并发症没有明显差异。

AIM:To compare one-site vs two-site phacotrabe-culectomy in chronic angle-closure glaucoma(CACG)coexisting with cataract.METHODS:This prospective,randomized study included 41 eyes with CACG.One-site approach was performed in 21 eyes and two-site procedure in 20 eyes.Intraocular pressure(IOP),best-corrected visual acuity(BCVA),the number of antiglaucoma medications and complications were observed.All patients were followed up for 9 months.RESULTS:There were no significant differences between the two groups preoperatively.IOP decreased from 22.7±4.9mmHg and 23.7±4.7mmHg preoperatively in one-and two-site groups to 18.0±1.2mmHg and 16.7±1.1mmHg 9 months after operation respectively(P<0.05).There were no significant differences in mean IOP between the two groups at any time(P>0.05).Decrease of the number of antiglaucoma medications and BCVA improvement were similar in both groups 9 months after surgery(P>0.05).There were no significant differences in complications between the two surgical procedures.CONCLUSION:There were no significant differences between the two groups in clinical efficacy and complications.

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