目的:阐明同种异体小鼠角膜移植术后免疫排斥反应及免疫赦免的相关性。方法:建立小鼠原位角膜移植及同种异体小鼠角膜移植实验模型。观察原位移植与同种异体移植术后角膜植片发生排斥的情况,对比两种移植术后植片的存活率,了解小鼠角膜移植术后发生排斥反应与免疫赦免反应之间的关系。结果:小鼠原位角膜移植术后植片100%存活;同种异体小鼠角膜移植术后存活率为25%。结论:小鼠角膜移植术后免疫排斥并非绝对,免疫赦免在角膜移植术中发挥重要作用。

·AIM:To study the correlation of immune rejection and immune privilege in homogeneity variant mice corneal transplantation model.·METHODS:The experimental animal model of mice normal position corneal graft and allograft was established successfully.Then,we observed the immune rejection of the two kinds graft model.The transplantation corneal survival rate was compared and analyzed according to the Sonoda method.·RESULTS:All the graft corneas following normal position transplantation were alive,compared with only 25% of allograft cornea alive.·CONCLUSION:Immune rejected reaction in mice corneal transplantation is not always happened and immune privilege plays a very important role in cornea graft.·

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中国广东省自然基金资助项目(No.9151051501000047);南方医科大学南方医院院长基金重点资助项目(No.2008A001)~~