目的:观察尚未发生眼底病变的糖尿病确诊患者在不同病程时期视网膜振荡电位(OPs)和视觉诱发电位(VEP)的变化情况。方法:采用国际标准法对35例70眼正常人进行OPs和VEP的检测,对94例188眼未发生眼底病变糖尿病确诊患者按病程长短分为3组,分别进行OPs和VEP的检测。结果:各实验组与对照组相比表现为OPs幅值的降低和VEP峰值降低,潜时值延长,P<0.01,有显著统计学差异。各实验组之间相比表现为病程越长OPs幅值越低和VEP峰值越低,潜时值越长,P<0.01,有显著统计学差异。结论:糖尿病患者在眼底尚无病变前,其OPs和VEP已经出现异常,并且随着糖尿病病程的延长,各项指标的变化更加明显。因此,采用OPs和VEP的联合检测可以为糖尿病视网膜病的早期诊断提供依据。

·AIM:To investigate the changes of retinal oscillatory potentials(OPs)and visual evoked potentials(VEP)in diabetes patients without the occurrence of retinopathy during different course of the disease.·METHODS:International Standards were adopted to 35 cases 70 eyes with normal OPs and VEP,and 94 patients 188 eyes diagnosed with diabetes without retinopathy occurence were divided into three groups according to duration of disease,and the OPs and VEP were detected.·RESULTS:The experimental group and control group showed reduction of OPs and decrease of VEP peak amplitude.There were statistically significant differences(P<0.01).The comparisons between the experimental groups showed that the longer duration,the lower amplitude OPs,and the lower the peak VEP,the longer the latent time(P<0.01).·CONCLUSION:Before there is fundus lesion in diabetic patients VEP and OPs have been abnormal,and with prolonged duration of diabetes,more obvious changes are observed in the indicators.Therefore,the use of OPs and PVEP for the joint detection underlies early diabetic retinopathy diagnosis.·

R774.1