目的:观察Matrix Aurium(Matrix400型)可变色蓝光滤过型人工晶状体的术后效果和视觉功能。方法:回顾性总结我院2007-09/2010-10老年性白内障患者(排除青光眼、角膜病变、葡萄膜炎、高度近视、黄斑病变等眼部疾病以及眼外伤等)共计49例57眼,行超声乳化吸除联合人工晶状体植入术,其中25例31眼植入Matrix Aurium(Matrix400型)可变色蓝光滤过型人工晶状体,24例26眼植入Matrix401型透明非蓝光滤过型人工晶状体作为对照组,观察两组患者术中术后并发症,术后3mo在明光(1000lux)、暗光(40lux)以及在同一时间户外阳光照射下的视力,应用美国国家眼科机构视觉功能调查表(National Eye Institute Visual Functioning Questionnaire-25,NEI VFQ-25)调查问卷,了解患者主观视觉感受,并随访患者在户外阳光下是否需要戴太阳镜。结果:除了术后轻度角膜水肿,所有患者手术中以及手术后均未出现严重并发症,我们观察到在户外自然阳光照射环境下Matrix Aurium可变色蓝光滤过型人工晶状体的确具有变色效果,术后3mo两组之间在明光(1000lux)、暗光(40lux)以及户外阳光下的视力无统计学差别(P>0.05)。Matrix Aurium变色蓝光阻断人工晶状体患者户外佩戴太阳镜的比率(6.5%)明显低于对照组(30.8%),差异有统计学意义(P=0.032),NEI VFQ-25在视觉功能调查各个项目中,两组之间未见明显差别(P>0.05)。结论:可变色蓝光滤过型人工晶状体Matrix Aurium植入人体眼内在自然户外阳光下具有变色效果,术后视力提高满意,初步观察具有良好生物学相容性,较普通人工晶状体减少户外戴镜现象,其远期效果以及对视网膜保护作用还需要长时间和多样本的研究。

AIM:To evaluate the result of the blue light-filtering photochromics IOL Matrix Aurium and compare patient-reported vision-related function between the blue light-filtering photochromic intraocular lens and a similar clear one that does not filter blue light. METHODS:Consecutively 57 eyes selected from 49 senile cataract patients who came from Beijing Prison Administration Bureau Central Hospital in 2007- 09/2010-10 were divided into two groups by their type of IOL according to their ideal:blue light-filtering photochromics IOL Matrix Aurium groups (Matrix 400) and a clear ultraviolet-filtering IOL (Matrix 401). The patients lived in Beijing or vicinity, which can be followed up in time. All patients performed phacoemulsification and IOL implantation,complications in operation or after operation were observed, and 3 months after operation several tests were done by the same technicians.The parameters included best corrective visual acuity (BCVA) under photopic(1000lux)and mesopic(40lux) and of the same time in sunlight outdoors, subjective visual quality was assessed with the National Eye Institute Visual Functioning Questionnaire-25 (NEI VFQ-25). Patients were investigated whether they had to wear sunglasses in sunlight outdoors. RESULTS:There were no other complications in or after operation except several mild corneal edema. We could observe that the blue light-filtering photochromics IOL Matrix Aurium could turn yellow in sunlight outdoors, about 6.5% patients needed a sunglass in Matrix 400 group, which was significantly lower than 30.8% in Matrix 401 group(P=0.032).There were no significant difference in BCVA under photopic(1000lux) or mesopic(40lux) or outdoors between two groups (P>0.05). There were no significant difference in mean NEI VFQ-25 scores. CONCLUSION:Blue light-filtering photochromics IOL Matrix Aurium has fuction of turning yellow in human’s eyes,povides good vision, and reduce the rate wearing sunglass in sunlight outdoors.Its retinal protective effects are needed for further study.

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