目的:观察视网膜色素变性(retinitis pigmentosa,RP)的全视野视网膜电图(global electroretinogram,ERG)、多焦视网膜电图(multifocal electroretinogram,mfERG)及视网膜光学相干断层扫描(optical coherence tomography,OCT)的图像特征及临床意义。方法:对临床确诊的RP患者组15例30眼和正常对照组15例30眼进行全视野ERG,mfERG与OCT检查,并对数据进行统计分析。结果:RP患者组全视野ERG显示b波潜伏期与正常对照组相比显著延长且b波振幅与正常对照组相比显著降低;mfERG各环的反应密度均低于正常对照组,且有显著性差异,3～5环的潜伏期与正常对照组相比显著延长。RP患者组OCT显示视网膜黄斑中心凹厚度平均值低于正常对照组,但二者比较,差异无统计学意义。结论:ERG可有效评价RP患者黄斑区及周边视网膜的功能,RP患者OCT断层扫描像与其已知的视网膜病变特点相一致。

AIM:To observe the characteristics of the images of global electroretinogram(ERG),multifocal electroretinogram(mfERG) and optical coherence tomonraphy(OCT) performed on the patients with retinitis pigmentosa(RP) and its clinical significance.METHODS:Fifteen RP patients(30 eyes) and fifteen normal control subjects(30 eyes) were tested with global ERG,mfERG and OCT.The data were processed with software SPSS.RESULTS:Global ERG showed the latency of b wave was significantly prolonged and its amplitude was significantly reduced in the RP group compared with normal control group.The response densities of five ring areas in RP were decreased while the latencies of ring 3,ring 4 and ring 5 were significantly prolonged compared with normal control group by mfERG.The retinal thickness of the macula was decreased compared with normal control group.Normal refractive image of thickness disappeared at fovea among the patients,but the difference was not significant.CONCLUSION:ERG can provide more information to evaluate the macular and periphery retina function effectively.OCT images in RP patients establish a correlation between known pathologic retina with RP and features evident on OCT.

R774.1