目的:分析2型糖尿病患者糖尿病视网膜病变(diabetic retinopthy,DR)相关危险因素。方法:2型糖尿病患者300例,根据有无DR及病变程度分为3组:正常视网膜(NDR)组、非增殖型视网膜病变(NPDR)组和增殖型视网膜病变(PDR)组进行临床分析。结果:和NDR组比较,NPDR、PDR组病程、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、2h血糖(2hPG)、糖化血红蛋白(HbA1c)、24h尿蛋白排泄量显著升高,差异有统计学意义(P<0.05)。Logistic回归分析表明:病程和SBP是DR发生的独立危险因素。结论:病程、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、2h血糖(2hPG)、糖化血红蛋白(HbA1c)、24h尿蛋白排泄量等因素与DR的发生有关,其中糖尿病病程及SBP是DR的独立危险因素。

AIM:To analyze the correlated risk factors of diabetic retinopathy(DR) in type 2 diabetes mellitus.METHODS:Three hundred cases with type 2 diabetes mellitus were divided into three groups:nondiabetic retinopathy group(NDR group),nonproliferative diabetic retinopathy group(NPDR group)and proliferative diabetic retinopathy group(PDR group)to analyze its correlated risk factors.RESULTS:Compared with NDR group,course of disease,systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting plasma glucose(FPG),2h plasma glucose(2h PG),HbA1c and 24 hour urinary protein excretion in NPDR group and PDR group were significantly higher(P<0.05);the result of logistic regression showed that diabetic duration and SBP were independent risk factors of DR.CONCLUSION:Diabetic duration and SBP are independent risk factors of DR.