目的:观察模拟高原缺氧环境对成年大鼠视网膜电流图(electroretinogram,ERG)的影响。方法:将45只Wistar大鼠随机分成3组,即650m海拔高度(乌鲁木齐所在海拔高度)组、模拟3000m海拔高度组、模拟5000m海拔高度组,分别将模拟3000m和5000m海拔高度组大鼠放入预先设定高度为3000m和5000m的低压舱内,饲养7d后测量大鼠F-ERGa波、b波及Ops潜伏期及波幅。结果:模拟5000m海拔高度组F-ERGa,b,Ops各子波OP1,OP2,OP3波峰值潜伏时与模拟3000m海拔高度组和650m海拔高度组比较都具有统计学意义(P<0.05);而模拟3000m海拔高度组F-ERGa,b,Ops各子波OP1,OP2,OP3波峰值潜伏时与650m海拔高度组比较无统计学意义(P>0.05);模拟5000m海拔高度组F-ERGa,b波幅及Ops总波幅与模拟3000m海拔高度组和650m海拔高度组比较都具有统计学意义(P<0.05);模拟3000m海拔高度组F-ERGa,b波幅及Ops总波幅与650m海拔高度组比较则无统计学意义(P>0.05)。结论:用低压舱模拟的5000m高原缺氧环境对大鼠的视网膜神经元造成损伤,而模拟3000m海拔高度的缺氧环境对大鼠视网膜神经元的损伤不明显。

AIM:To investigate the effects of ERG in rats at simulated plateau-hypoxia environment.METHODS:Forty-five healthy Wistar rats were randomly divided into 650m(the altitude of Urumchi)altitude group,simulated 3000m altitude group and simulated 5000m altitude group.Rats in simulated 3000m altitude group and simulated 5000m altitude were put into the 3000m altitude hypobaric chamber and the 5000m altitude hypobaric chamber respectively.All of them underwent F-ERG a wave,b wave and Ops tests at the 7th day after bred.RESULTS:The amplitudes of F-ERG a wave,b wave and Ops in the simulated 5000m altitude group were significantly lower than those in the 650m altitude group and the simulated 3000m altitude group.The latencies of ERG and Ops were delayed in the simulated 3000m altitude group rats,without significant differences compared with the 650m altitude group(P>0.05).There were significant differences in the latencies of ERG and Ops between the 650m altitude group and the simulated 5000m altitude group,the simulated 3000m altitude group and the simulated 5000m altitude group(P<0.05).But there were no significant differences in the latencies of ERG and Ops between the simulated 3000m altitude group and the 650m altitude group(P>0.05).CONCLUSION:The retinal neurons were damaged in the simulated 5000m altitude group,which was not significant in the simulated 3000m altitude group.

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