目的:应用光学相干断层扫描仪(optical coherence tomography,OCT)检测豚鼠眼视网膜、脉络膜厚度及结构形态,探讨OCT检测豚鼠眼视网膜、脉络膜厚度与组织学检查结果的相关性。方法:对5只英国属花色豚鼠(出生后3wk)采用OCT扫描眼底并进行分析,然后处死豚鼠(10眼)行组织学检查。结果:OCT检测豚鼠视网膜厚度与组织学检查结果具备良好相关性(r=0.77,P<0.01),OCT检测视网膜厚度比组织学检查结果厚15～20μm。但豚鼠脉络膜厚度与组织学检查结果无明显相关性(r=0.19,P=0.203>0.05)。结论:豚鼠视网膜和脉络膜厚度均可通过OCT进行检测。

AIM:To detect the thickness and structural profiles of the retina and choroid in guinea pig eyes by optical coherence tomography (OCT),and discuss the correlation of thickness of the retina and choroids in guinea pig and histology examination.METHODS:Five guinea pigs (3 weeks old) underwent refractive evaluation in both eyes followed by routine OCT for posterior pole of the fundus.Then these 5 guinea pigs were euthanized and underwent histology examination.RESULTS:There was a highly positive correlation in retinal thickness between OCT and histology (r=0.77,P<0.01).The retina thickness by OCT was 15-20μm thicker than that by histology.But there was no significant correlation in choroid thickness between OCT and histology (r=0.19,P=0.203).CONCLUSION:Thickness of the retina and choroid in guinea pigs both can be detected by routine OCT.

R774.1