目的:观察老年性白内障患者术前应用氧氟沙星滴眼液对结膜囊细菌培养的影响。方法:老年性白内障患者30例60眼,随机分成两组:对照组15例30眼,3g/L氧氟沙星点眼组15例30眼,平均点眼5次,l滴/次。观察点药前,点药l,2,3d,结膜囊内细菌的变化。结果:点药前,点药1,2,3d,结膜囊内细菌落积分的变化:对照组,51,51,33,42;3g/L氧氟沙星点眼组,51,30,9,0。配对t检验统计分析,点药3d,P=0.043。结膜囊内细菌检出率的变化:对照组,60%,60%,40%,50%;3g/L氧氟沙星点眼组,60%,30%,10%,0。χ2检验,点药3d,P<0.01。结论:老年性白内障患者术前应用氧氟沙星滴眼液点眼,3d可以达到结膜囊内无细菌。

AIM: To investigate the effect of ofloxacin eye drop on bacterial culture of the conjunctival sac in senile cataract patients. METHODS: Thirty cases (60 eyes) with senile cataract were randomized into two groups: the control group (15 cases, 30 eyes) and the ofloxacin group (15 cases, 30 eyes). The ofloxacin group received 3g/L ofloxacin eye drop five times per day and one drop per time. Bacterial culture was done before treatment and at day 1, 2 and 3 of treatment. RESULTS: The cumulative score of bacterial colonies in the conjunctival sac for the control group was 51, 51, 33, and 42 respectively, and for the ofloxacin group, 51, 30, 9 and 0 respectively. Paired t-test showed a P value of 0.043 at day 3 of treatment. The positive rate of bacteria in the conjunctival sac for the control group was 60%, 60%, 40%, and 50% respectively, and for the ofloxacin group, 60%, 30%, 10%, and 0% respectively. The Chi-squared test showed P<0.01 at day 3 of treatment. CONCLUSION: Using ofloxacin eye drop for 3 days before surgery can eliminate the bacterial flora of the conjunctival sac in senile cataract patients.

R779.6