目的:通过横断面数据分析,了解儿童身高、体质量与眼部生物学参数的关系。方法:选择广州双生子眼病研究(Guangzhou Twin EyeStudy)项目7～15岁双生子队列人群。所有参加检查的双生子都进行眼科检查,包括裸眼视力、散瞳验光、双眼视功能、屈光间质、眼底以及眼球生物学参数眼轴长度、前房深度、角膜曲率半径。所有双生子都记录身高和体质量。通过多元线性回归模型进行分析。结果:7～15岁双生子儿童的眼部生物学参数眼轴、前房深度都随身高、体质量的增长而增长,而角膜曲率半径与身高、体质量的变化没有关系。在校正年龄和性别后,身高每增加1cm,等效球镜降低0.03D,眼轴增长0.03mm,前房加深0.002mm。在校正年龄和性别后,体质量的变化与眼部生物学参数无关。结论:7～15岁双生子儿童的身高与等效球镜、眼轴长度、前房深度的变化有关,体质量与等效球镜、眼轴长度、前房深度的变化无关。

AIM:To explore the relationships between height,weight and refraction and ocular biometries in children by cross-sectional study.METHODS:Study participants were recruited from the Guangzhou Twin Registry.The examination included visual acuity measurements,ocular motility evaluation,autorefraction under cycloplegia,and examination of the anterior segment,media,fundus.Axial length,anterior chamber depth,cornea curve radius was measured using partial coherence laser interferometry.Height and weight were measured with the participants standing without shoes.A multivariate linear regression model was used.RESULTS:Both axial length and anterior chamber depth grew with height and weight increase,but cornea curve radius kept steady.Adjusted by age and gender,spherical equivalent decreased-0.03D,axial length increased 0.03mm,anterior chamber depth deepened 0.002mm with 1cm height increase.But there was no association between weight and ocular biometries.CONCLUSION:There are associations between height and spherical equivalent,axial length,anterior chamber depth,and no association between weight and spherical equivalent,axid lenqth as well as anterior chamber depth.

国家自然科学基金资助项目(No.30772393);中国教育部博士点专项科研基金资助项目(No.20100171110076)~~