目的:利用第三代光学相干断层扫描仪(3D-OCT)对屈光不正性弱视儿童患者黄斑中心凹及视神经纤维层厚度进行定量分析,比较其与正常儿童的差异。方法:选取于我院就诊的屈光正性弱视患者20例40眼,年龄4～10(平均6.15±1.64)岁,等效球镜1.50～7.00D,眼轴22.07±0.97mm;正常对照组25例50眼,年龄4～15(平均8.62±2.42)岁,等效球镜0.57±1.07D;眼轴22.81±0.72mm。利用第三代光学相干断层扫描仪(3D-OCT)分别对其黄斑中心凹和视神经纤维层厚度进行测量,所得数据应用SPSS13.0统计软件进行独立样本t检验、Pearson检验,比较其与正常对照组的差异。结果:弱视眼与正常眼黄斑中心凹厚度分别为132.98±14.99μm和136.60±13.82μm,比较无显著性差异(P>0.05);平均视神经纤维层厚度分别为116.95±9.59μm和110.40±7.63μm,比较有显著性差异(P<0.01);正常对照组平均视神经纤维层厚度与眼轴呈负相关(r=-0.31,P<0.05),弱视组平均视神经纤维层厚度与眼轴无明显相关性(r=0.12,P>0.05)。结论:屈光不正性弱视可能影响视神经纤维层厚度,但具体机制尚需进一步研究。

AIM:To assess and compare the thicknesses of central fovea of macula and retinal nerve fiber layer in normal children and children with ametropic amblyopia.METHODS:Optical Coherence Tomography(OCT) was performed on 20 children(40 eyes) with ametropic amblyopia,the mean age was 6.15±1.64 years old,spherical equivalent was 1.50-7.00D,axis oculi was 22.07±0.97mm;OCT was also performed on 25 normal children(50 eyes),the mean age was 8.62±2.42 years old,spherical equivalent was 0.57±1.07D,axis oculi was 22.81±0.72mm.Thicknesses of central fovea of macula and retinal nerve fiber layer were measured.In this study,t-test and Pearson test with SPSS 13.0 software were used to assess and compare the thicknesses of central fovea of macula and retinal nerve fiber layer in normal children and children with ametropic amblyopia.RESULTS:The average thickness of the fovea was 136.60±13.82μm in normal eyes and 132.98±14.99μm in amblyopic eyes.The difference between the two groups was not statistically significant(P>0.05).The average thicknesses of the retinal nerve fiber layer was 110.40±7.63μm in normal eyes and 116.95±9.59μm in amblyopic eyes.The difference between the two groups was statistically significant(P<0.01).There was negative correlation between average thicknesses of the retinal nerve fiber layer and axis in normal eyes(r=-0.31,P<0.05),but there was no significantly correlation in amblyopic eyes(r=0.12,P>0.05).CONCLUSION:Retinal nerve fiber layer thickness may be affected by ametropic amblyopia,but further histopathologic confirmation is needed.

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