长期慢性的紫外线(UV)辐射被认为是老年性白内障形成的重要原因。皮质型和混合型白内障的发生与UV辐射关系密切。大量的流行病学研究表明,导致皮质型白内障发生的10%～30%相对危险因素可以归结于射线辐射。UV辐射,特别是UVB是皮质型白内障发生的重要危险因素。晶状体上皮细胞是晶状体代谢最活跃的部位,也是UV作用的重要靶组织。晶状体上皮细胞的过度凋亡以及晶状体蛋白损伤与白内障的发生、发展密切相关。

Chronic ultraviolet(UV) radiation is considered to be important reason of the senile cataract formation.A large number of epidemiological investigations have shown that cortical and mixed cataracts are subjected to UV radiation.10% to 30% relative risk can be attributed to solar radiation.UV radiation,particularly UVB is an important risk factor for cortical cataract.The lens epithelial cells is not only the most active part of the lens metabolism,but also an important target tissue for UV.The over-apoptosis of lens epithelial cells and the damage of lens protein are closely relevant to the occurrence and development of cataract.

R776.1

中国山东省自然科学基金资助项目(No.ZR2010HM032)