后发性白内障(posterior capsule opacification,PCO)是白内障手术后较为常见的并发症。近年来随着分子生物学及细胞生物学技术的发展,发现生长因子类物质如血小板源性生长因子(platelet-derived growth factor,PDGF)与晶状体上皮细胞的增殖、迁移、纤维分化有密切的关系,对PDGF进行适当的调控可能对于防治PCO有重要意义。我们围绕PDGF对晶状体上皮细胞的作用、PDGF及其受体对PCO形成的影响作简要综述。

Posterior capsule opacification is a more common complication after cataract surgery.In recent years,with the development of molecular biology and cell biology technology,growth factor-type substances such as platelet-derived growth factor(PDGF) are found closely related with proliferation,migration,and differentiation of lens epithelial cell.The appropriate regulation of PDGF may be very important for the prevention of after cataract.This paper focuses on effect of PDGF on lens epithelial cells,effect of PDGF and its receptors on after-cataract formation in a brief review.

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