胸腺素β4(thymosin beta 4,Tβ4)作为一种主要的G-肌动蛋白偶联蛋白存在于绝大多数哺乳动物细胞,具有促进细胞迁移、干细胞分化、血管形成,并抗细胞凋亡、调节免疫功能等多种生物学作用,在创伤修复、肿瘤转移、控制炎症等过程中发挥重要作用。我们就Tβ4对细胞迁移和转分化的影响及其在眼科的研究进展进行综述。

As a major G-actin-sequestering protein,thymosin beta4(thymosin β4,Tβ4) is in almost mammalian cells.It has a number of physiologic functions,including the promotion of cell migration,stem cell differentiation,angiogenesis,inhibition of cell apoptosis and immune regulation,which plays an important role in the wound healing,tumor metastasis,inflammation control and so on.This review summarizes relative studies about Tβ4,including its properties in cell migration,transdiffe-rentiation and research progress in ophthalmology.

R77