目的：探讨新疆维吾尔族干眼症患者结膜上皮细胞的趋化因子受体-5(CCR5)的表达及临床意义。 方法：在新疆医科大学第一附属医院眼科门诊选择符合诊断、纳入和排除标准的干眼症患者30例60眼和正常人30例60眼，采用结膜印记细胞学的方法获取干眼症患者和正常人的结膜上皮细胞后，分别浸入有对应编号的离心管中，并应用免疫组织化学印记细胞学细胞涂片的方法检测正常人和干眼症患者结膜上皮细胞中CCR5的表达。 结果：干眼症组患者结膜上皮细胞中CCR5的阳性表达率均高于正常人（P＜0.05），且该因子的表达与BUT和Schimer Ⅰ试验均呈负相关，与角膜荧光素染色呈正相关。 结论：在干眼症发生的机制中，CCR5起到炎性介质的作用，其表达水平变化反映了干眼症的进展过程。

AIM:To explore the expression and clinical significance of chemotactic factor receptor-5(CCR5) of dry eye syndrome patients conjunctival epithelium in Xinjiang Uygur nationality. METHODS: Thirty dry eye syndrome cases(60 eyes) in the outpatient of the first affiliated hospital of Xinjiang Medical University and thirty non-dry eye syndrome cases(60 eyes) were selected,and the conjunctival epithelial cells in dry eye syndrome and non-dry eye syndrome cases were obtained by impression cytology methods,and then immersed into the centrifugal tube with corresponding number respectively and the expression of CCR5 in conjunctival epithelium of dry eye syndrome and non-dry eye syndrome cases were detected by immunohistochemical method. RESULTS: Positive expression rate of CCR5 in dry eye syndrome cases was more obvious than that in non-dry eye syndrome cases(P＜0.05). Expression rate of CCR5 in dry eye syndrome cases was negatively correlated with Schirmer Ⅰ test and break-up time(BUT); however it was positively related with corneal fluorescence staining. CONCLUSION: CCR5 plays an inflammatory mediators role in dry eye syndrome mechanism and its expression level reflects the progress of dry eye syndrome.