年龄相关性黄斑变性(age-related macular degeneration,AMD)是西方国家首要的不可逆的致盲眼病,随着中国老年化的日益加剧，我国的AMD患者亦日益增加，而其发病机制尚未明确。探讨载脂蛋白E（ApoE）基因与AMD两者之间的内在联系，对AMD的预防、诊断及治疗具有重要的临床应用价值。

Age-related macular degeneration (AMD) is the first irreversible blind eye disease in western countries. With China’s population aging growing, AMD patients in China are also increasing, but its pathogenesis remains unclear. It plays an very important role in AMD prevention, diagnosis and treatment in clinical application,by exploring the internal relations between apolipoprotein E gene and AMD.