目的：探讨中央角膜厚度（central corneal thickness, CCT）对24h眼压波动的影响。 方法：使用Goldmann眼压计测量39例78眼未治疗的青光眼患者和44例88眼年龄匹配的正常对照眼的24h眼压波动（5am,7am,10am,2pm,6pm,10pm），并用超声测厚仪测量CCT。 结果：青光眼组和对照组的平均眼压分别为21.33±2.91和16.19±2.33mmHg（t=12.615，P=0.000）；峰值分别为24.67±2.72和18.55±2.45mmHg（t=12.613，P=0.000）；波动值分别为6.63±3.26和4.72±1.60mmHg（t=4.709，P=0.000）；CCT分别为544.44± 32.11和537.16±27.66μm（t=1.569，P=0.119）。CCT与青光眼组的眼压波动值无显著相关性（r=0.140，P=0.222）；CCT与对照组的眼压波动值亦无显著相关性（r=0.050，P=0.642）。以CCT＜545μm为薄角膜组，CCT≥545μm为厚角膜组进行对比分析，青光眼组和对照组的平均眼压、峰值、波动值的差异无显著性（P＞0.05）。 结论：CCT与24h眼压波动无显著相关性。

AIM:To evaluate the effects of central corneal thickness (CCT) on 24-hour intraocular pressure (IOP) fluctuation. METHODS: Measurements of IOP were obtained by Goldmann applanation tonometer on 5am,7am,10am,2pm,6pm,and 10pm during a 24-hour period from 39 untreated glaucoma patients and 44 age-matched normal control subjects. CCT was measured in all subjects using ultrasound pachymetry. The association between IOP fluctuation (peak IOP-trough IOP) during the 24-hour period and the CCT was assessed in both glaucoma patients and healthy age-matched controls using Spearman correlation. RESULTS: The average 24-hour IOP, peak IOP, IOP fluctuation and CCT in glaucoma group and control group were 21.33±2.91mmHg and 16.19±2.33mmHg（t=12.615，P=0.000）, 24.67±2.72mmHg and 18.55±2.45mmHg（t=12.613，P=0.000）, 6.63±3.26 mmHg and 4.72±1.60mmHg（t=4.709，P=0.000）, 544.44±32.11μm and 537.16±27.66μm（t=1.569，P=0.119）, respectively. The average 24-hour IOP, peak IOP and IOP fluctuation were significantly different between normal and glaucomatous patients. The CCT, however, was not significantly different between the two groups. There was no statistically significant correlation between IOP fluctuation and CCT in glaucomatous (r=0.140，P=0.222) and normal subjects (r=0.050，P=0.642). There was no significant difference in average 24-hour IOP, peak IOP or IOP fluctuation between glaucomatous patients and normal subjects with thick(CCT≥545μm) and thin corneas(CCT＜545μm). CONCLUSION:Twenty-four-hour IOP fluctuations are not correlated with CCT measurements in glaucoma patients and normal subjects.