目的：比较盐酸氮卓斯汀滴眼液和富马酸依美斯汀滴眼液治疗变态反应性结膜炎的疗效。 方法：应用盐酸氮卓斯汀滴眼液和富马酸依美斯汀滴眼液分别治疗两组变态反应性结膜炎患者，双眼2次/d，1滴/次，间隔12h，治疗14d后停药。分别在开始治疗后3,7,14d和停药后7d随访观察。 结果：用药后3d，两组间治愈率和有效率有统计学差异(P<0.05，P<0.01)。用药后7，14d和停药后7d，两组间治愈率和有效率的差异均无统计学意义(P>0.05)。 结论：在变态反应性结膜炎的疗效方面，盐酸氮卓斯汀滴眼液与富马酸依美斯汀滴眼液的应用均安全有效。但在用药早期,盐酸氮卓斯汀滴眼液明显优于富马酸依美斯汀滴眼液,作用更迅速，效果更明显。

AIM:To compare the curative effect on allergic conjunctivitis between azelastine hydrochloride eye drops and emedastine difumarate eye drops. METHODS:Two groups with allergic conjunctivitis were treated with azelastine hydrochloride eye drops and emedastine difumarate eye drops separately, twice a day, one drop per time,at interval of 12 hours, the treatment stopped after 14 days.The follow-up observations were done in 3 days, 7 days and 14 days during treatment as well as 7 days after finishing treatment. RESULTS:With 3 days treatment, the differences between these two groups on curative ratio(P<0.05) and effective ratio (P<0.01) were significant. But with 7 days and 14 days treatment as well as 7 days after treatment, the differences were not significant. CONCLUSION:On the treatment for allergic conjunctivitis, both of azelastine hydrochloride eye drops and emedastine difumarate eye drops have safe effect, but in the early stage, the effect of azelastine hydrochloride eye drops is better and more obvious.