目的：探讨薄瓣LASIK术后6mo内中央角膜厚度(central corneal thickness, CCT)及屈光度的变化规律。 方法：使用非接触式角膜内皮细胞计追踪观察158例302眼近视眼行LASIK手术患者术前及术后1d;1wk;1,3,6mo时CCT的变化，同时记录患者的年龄，预计激光角膜切削值、术中手术光区的大小，术后预计屈光度以及实际屈光度的改变等。 结果：术前平均CCT为531.6±24.3μm。术后第1d平均CCT迅速下降，术后1wk平均CCT继续下降， 1mo后角膜厚度开始增厚。术前和术后第1d CCT差值与预计激光角膜切削值呈强相关性（r＝0.916，P<0.01）。术后6mo和术后1d时CCT的差值，即6mo内CCT的增厚值与患者年龄、术眼屈光度和术中手术光区均呈显著负相关性（r＝ -0.180，P＝0.026；r＝-0.187，P<0.01；r＝-0.171，P＝0.137）。术后6mo时,实测平均等效球镜与术前预期值接近（术前等效球镜预期值平均为0.34±0.30D）。所有病例随访6mo，无1例发生屈光回退，6mo时裸眼视力均≥0.8，平均视力为1.3±0.2。 结论：薄瓣LASIK术后CCT和屈光状态的稳定大约需要6mo时间。术后6mo内CCT增厚值与术前患者年龄、屈光度及术中手术光区大小均呈显著负相关性。术后6mo时实测平均等效球镜值与术前预期值接近。薄瓣LASIK手术治疗近视眼具有良好的预测性和稳定性。

AIM:To analyze the changes of central corneal thickness (CCT) and refractive error in post thin-flap laser in situ keratomileusis (LASIK) eyes. METHODS:Totally 158 myopic patients (302 eyes) having thin-flap LASIK were prospectively evaluated. CCT and refractive error were measured before and 1 day, 1 week, 1 month, 3, 6 months after surgery. Age, predicted photoablation depth, optic zone ,postoperative predicted diopter and actual diopter changes were also recorded. RESULTS:Preoperatively, the mean CCT was 531.6±24.3μm. On the first day postoperatively, CCT rapidly decreased. At 1 month, it was 427.2±38.0μm. At 3 months, it was 434.4±38.2μm, and at 6 months, it was 435.6±38.0μm. The CCT difference before and 1 day after LASIK was highly correlated with predicted photoablation depth（r=0.916, P<0.01）. The increase of corneal thickness in post LASIK eyes in 6 months was negatively correlated with age, preoperative refractive error, and optical zone, respectively (r=-0.180, P=0.026; r=-0.187, P<0.01; r= -0.171, P=0.137, respectively). The spherical equivalent refraction at 6 months was close to the preoperative predicted values. All patients were followed up for six months, no case of refractive regression occurred.At 6 months, all the uncorrected visual acuity was≥0.8, the average visual acuity was 1.3±0.2. CONCLUSION:At 6 months after surgery, CCT and spherical equivalent refraction were relatively stable. The increase of CCT in post thin-flap LASIK eyes in 6 months was negatively correlated with age, preoperative refractive error, and optical zone, respectively. The spherical equivalent refraction at 6 months was close to the preoperational predicted values. The treatment of myopia in thin-flap LASIK has a good accuracy, and a long-term prediction.