目的：探讨鼻内窥镜下鼻腔泪囊造孔术中骨孔的大小对手术效果的影响,以寻求最合适的骨孔大小。 方法：采用随机、单盲、平行研究方法。选取2010-01/10在株洲三三一爱尔眼科医院欲行鼻内窥镜下鼻腔泪囊造孔术治疗的慢性泪囊炎患者200例200眼随机分成两组：A组100眼：骨孔大小6mm×6mm（±2mm），B组100眼：骨孔大小10mm×10mm(±2mm)以上。手术时按分组做相应大小骨孔，术后观察各种不良反应及手术效果。 结果：A组9例因骨壁太厚，3例因骨孔位置不在最佳位置需扩大骨孔，失访4例，最后进入观察病例84例，其中无效2例,有效82例。B组失访3例，最后进入观察病例97例，其中无效3例,有效94例，两组统计学上成功率无明显差别，A组患者术后反应更小效果更好。 结论：鼻内窥镜下鼻腔泪囊造孔手术治疗慢性泪囊炎时6mm×6mm(±2mm)的骨孔大小是合适的，具有微创、术中出血少、术后不良反映少、且不影响手术效果的特点。

AIM:To discuss the effect of bone hole size in nasal endoscopic dacryocystorhinostomy on the operation results to find the most appropriate size of the bone hole. METHODS:A randomized, single-blind, parallel study. 200 cases of 200 eyes of chronic dacryocystitis for nasal endoscopic dacryocystorhinostomy treatment in Zhuzhou 331 Aier Eye Hospital from 2010-01 to 2010-10 were randomly divided into two groups: A group of 100 eyes: bone hole size was 6mm×6mm (±2mm), B group of 100 eyes: bone hole size was10mm×10mm(±2mm) or more. Surgery was done with corresponding size of the bone hole by grouping, various adverse effects and results of operations were observed postoperatively. RESULTS:In A group, 9 cases of bone thick-walled and 3 cases of bad bone hole location needed to expand the bone hole, 4 cases were lost, 84 cases finally entered the observed cases, including 2 ineffective cases and 82 effective cases. In B group, three cases were lost, and 97 cases finally entered the observed cases, including 3 ineffective cases and 94 effective cases.The two groups had no statistically significant difference in success rate, patients of A group had less postoperative reaction and responded better. CONCLUSION:The bone hole size of 6mm×6mm (±2mm) is appropriate for nasal endoscopic dacryocystorhinostomy to treat chronic dacryocystitis, featured by minimally invasive, less bleeding, less postoperative adverse reactions and no affecting results of operations.