目的：研究bFGF在早产儿视网膜病变（ROP）大鼠模型中的表达水平，以探讨ROP可能的发病机制。 方法：以SD大鼠为模型动物，用高氧诱导建立模型，采用免疫组织化学SABC法检测bFGF蛋白水平，逆转录聚合酶链式反应（RT-PCR）法检测bFGFmRNA水平。 结果：SABC法显示正常组中bFGF蛋白微弱阳性染色，而高氧组阳性染色明显增强，前者灰度平均值明显高于后者，差异有统计学意义(P＜0.05)；RT-PCR法显示高氧组bFGFmRNA与GAPDHmRNA的比值显著高于正常组，其差别亦有统计学意义(P＜0.05)。 结论：bFGF参与了视网膜新生血管（RNV）的形成，与ROP的发病机制有关。

AIM: Formation of RNV is the most important pathological change in retinopathy of prematurity(ROP),but its exact procession and mechanism is not discovered. This research was carried to detect the expression of basic fibroblast growth factor(bFGF) in rat models of ROP, in order to discuss the mechanism of ROP. METHODS: Forty new-born SD rats were classified into two groups: one was normal group and the other was hyperoxia group.The rats of hyperoxia group were bred in hyperoxia environment for 5 days from the seventh day to establishing the model. Strept avidin-biotin complex(SABC) was used to detect the level of bFGF protein, RT-PCR to detect bFGFmRNA. RESULTS:The level of bFGF protein and bFGFmRNA in the hyperoxia group were both obviously higher than the normal group,and there was statistical significance. CONCLUSION: Formation of RNV is relative to bFGF, bFGF plays a role in ROP.