目的：探讨胰岛素样生长因子-1（IGF-1）及胰岛素样生长因子结合蛋白-3（IGFBP-3）在大鼠视网膜缺血再灌注损伤（RIRI）后的表达规律及相关性。 方法：建立大鼠视网膜缺血再灌注模型，应用免疫组织化学法检测大鼠RIRI后视网膜组织IGF-1和IGFBP-3表达的变化规律，对两者进行相关性分析。 结果：正常视网膜组织IGF-1和IGFBP-3即有轻微表达，IGF-1在缺血再灌注后6h表达明显增高，72h达到高峰，IGFBP-3在缺血再灌注后12h表达明显增高,72h达到高峰，且二者具有相关性。 结论：IGF-1和IGFBP-3表达与RIRI有关，两者呈正相关。

AIM:To investigate the expression pattern and correlation of insulin-like growth factor-1 (IGF-1)and its binding protein-3(IGFBP-3) in the ischemia-reperfusion in rats. METHODS:The models of retinal ischemia-reperfusion in rats were made.In order to analyze the correlation and expression between IGF-1 and IGFBP-3 in retinal ischemia-reperfusion model,immunohistochemical method was used. RESULTS:In the normal retina,IGF-1 and IGFBP-3 were slightly expressed,while in retinal ischemia-reperfusion group,the expression of IGF-1 ascended obviously at 6 hours,reached peak at 72 hours; the expression of IGFBP-3 ascended obviously at 12 hours,reached peak at 72 hours，and the two had a collaborative relationship. CONCLUSION: IGF-1 and IGFBP-3 expression are closely related to retinal ischemia-reperfusion injury,and have a positive correlation.