眼科多种病变均可导致相关部位的缺血缺氧甚至新生血管的形成，极大地影响了患者的治疗和预后，在新生血管形成的相关因素的研究中，缺氧诱导因子（hypoxia-inducible factor l，HIF-1）的研究成为其中的一个新兴热点，其在相关病变中的阳性表达及机制探讨为临床治疗提供了新的治疗策略。现将HIF-1在眼科相关疾病中的研究进展做一综述。

Many eye lesions which can lead to ischemia and anoxia of the related parts and even the formation of new blood vessels has greatly affected the treatment of patients and prognosis.In the study of relevant factors for new blood vessels formation, hypoxia-inducible factor 1(HIF-1) research becomes one of the emerging hot spots, its positive expression in the related lesions and mechanism discussion provides new treatment strategies for clinical treatment.Now the HIF-1 research progresses in the eye related disease are reviewed in this paper.