目的：分析眼部黑色素瘤临床和病理学特点，以利于早期正确诊断和治疗。 方法：回顾性系列病例研究。收集我院2001-08/2011-08门诊及住院眼部黑色素瘤24例，复习患者的临床和病理资料，所有病例采用常规石蜡切片、HE染色，部分病例常规诊断困难的加做S-100蛋白和HMB-45免疫组织化学染色。Excel建立数据库，应用SPSS 17.0软件进行统计学分析。 结果：患者24例均为单眼发病，男13例,女11例；左眼14例，右眼10例；3例眼睑恶性黑色素瘤，6例原发性结膜黑色素瘤；15例葡萄膜黑色素瘤。 结论：黑色素瘤组织病理学变化多样，多数病例常规病理确诊，免疫组织化学对黑色素瘤诊断和鉴别诊断有重要价值。

AIM:To analyse ocular melanomas clinical and pathological specifics for earlier diagnosis and treatment. METHODS:Twenty-four cases with ocular melanoma were retrospectively collected during July 2002 to July 2011 and patients clinical and pathological history were reviewed. All samples had routine paraffin section, HE dying and some difficult diagnosed samples plus S-100 protein and HMB-45 s-p immunohistochemical method. Excel was used for establishment of a database and software SPSS 17.0 applied for statistical analysis. RESULTS:All 24 cases were ocellus, with 13 males and 11 females; 14 left eyes and 10 right eyes; 3 cases of eyelid malignant melanoma, 6 cases of primary malignant melanoma of conjunctiva and 15 cases of uveal melanoma respectively. CONCLUSION:Diversity of melanoma histopathology exists. Most cases can be confirmed by routine pathological method. Immunity histochemistry is of high value for diagnosis or differential diagnosis of melanoma.