目的：探讨多层羊膜覆盖治疗角膜穿通伤的疗效，为角膜穿通伤患者提供一种新的治疗方法。 方法：对20例20眼外伤性角膜缺损并穿孔的患者采用多层羊膜覆盖，术后随访3~6mo，观察前房形成，羊膜持续时间，术后视力变化等。 结果：患者20例术后第1d前房均形成。术后1mo穿孔愈合,角膜修补处呈半透明状混浊,未见新生血管长入，术后本组病例的视力均无提高。 结论：多层羊膜覆盖是治疗角膜穿通伤有效、安全的方法，它能维持眼球结构的完整，减轻了炎症反应，为后续的穿透性角膜移植创造了良好的条件。

AIM:To investigate the efficacy of multilayer amniotic membrane cover for traumatic corneal perforation and provide a new solution for patients treatment. METHODS:Totally 20 cases (20 eyes) with traumatic corneal perforation were treated with multilayer amniotic membrane cover for corneal perforation. Follow-up ranged 3-6 months. The formation of anterior chamber, duration of the amniotic membrane and visual acuity changes were observed. RESULTS:The anterior chamber reformed at the first postoperative day in all cases. The amniotic membrane covering the surface of cornea began to dissolve one week after the surgery. The epithelialization was observed one mouth after the surgery, perforation area healed with scar tissue. The vision was not improved in all patients after operation. CONCLUSION:Multilayer amniotic membrane cover is an effective and safety method for traumatic corneal perforation. It can maintain the eyeball structure complete, relieve the inflammation and provide good condition for further penetrating keratoplasty.