目的：报道利用玻璃体切割手术(pars plana vitrectomy,PPV)和缝线成功取出巨大球内异物(intraocular foreign body, IOFB)。 方法：在CT和球内异物的图片的指导下，采用玻璃体切割术联合7-0缝线取出球内巨大异物。 结果：两例都行玻璃体切割、晶状体切割、球内注射2.5mg头孢他啶和1mg万古霉素，第一例用缝线经角膜缘取出异物，第二例从角膜伤口处取出。视网膜裂孔周围行球内光凝，两例都填充硅油。术后随访，炎症都得到控制，成功地解剖复位。 结论：我们报道的为首例利用7-0缝线所做的圈套将球内异物经角膜取出，无需扩大巩膜切口从而避免了对视网膜造成严重的、不可逆的损害.

AIM: To report the successful use of pars plana vitrectomy (PPV) and polyglactin suture to extract large intraocular foreign body(IOFB). METHODS: We report two cases of large IOFB extraction from cornea assisted with PPV and 7-0 polyglactin suture with computerized tomography scans and pictures of the IOFBs. RESULTS: Both cases underwent vitrectomy, lensectomy, intravitreal injections of 2.5mg Ceftazidime and 1mg Vancomycin Hydrochloride, IOFB removal with 7-0 polyglactin suture via a limbal tunnel incision in the first case, and the original corneal laceration in the second. Laser endophotocoagulation was placed around the retinal break at the impact sites, with silicone oil tamponade in both cases. Inflammation was controlled, with successful anatomic restoration in postoperative follow-up.CONCLUSION: We describe, for the first time, removal of the large IOFBs with coil made with 7-0 polyglactin suture from cornea and to be an effective approach in removing large IOFBs without enlarging the sclerotomy to avoid severe and irreversible damage to the retina.