目的：探讨经缝线法行睑外翻手术建立“蒸发过强型”兔干眼模型的有效性和可行性。 方法：新西兰大白兔6只（12眼），每只兔随机选1眼行睑外翻手术(实验眼)，对侧眼作空白对照(对照眼)。分别于手术前及手术后 1，3，5，7，14，28d行泪液分泌试验、荧光素钠染色、1%虎红染色检查，术后第28d处死实验兔，取结膜、角膜、泪腺组织行眼科病理检查。 结果：泪液分泌试验结果显示：除实验前和实验后第1d，其余各时间点实验眼与对照眼相比，结果均有不同程度降低，且有统计学差异 (P<0.05)。实验眼术后第5d角膜开始出现荧光素钠着色，在术后第5d着色最重，之后出现不同程度的好转。实验眼术后第1d角结膜即出现轻度虎红着染，术后第14d着色最重，至28d时略有好转。组织病理学检查示：实验眼与对照眼相比，角膜上皮层次增加，表层扁平细胞不规则缺失，细胞排列紊乱；结膜上皮表面凹凸不平，细胞扁平增大，杯状细胞代偿性增生；泪腺组织光镜下未见明显异常改变。 结论：缝线法睑外翻手术制备兔干眼模型效果稳定、操作简便、成本低廉，是一种值得推广的干眼模型制作方法。

AIM: To evaluate the efficiency and feasibility of “excessive evaporation” rabbit dry eye model by ectropion surgery. METHODS: Dry eye models of rabbits were established by ectropion surgeries in a random eye of 6 New Zealand rabbits, while the other eyes of the rabbits were used as control. Schirmer Ⅰ test(SⅠt), fluorescence staining and 1% rose Bengal staining were performed before and 1, 3, 5, 7, 14, 28 days after surgery. Cornea, conjunctiva and lacrimal glands tissues biopsy was carried out under light microscope. RESULTS: SⅠt was significantly abnormal after surgery except the first day(P<0.05). Fluorescence staining showed on the 5^th days after surgery and appeared most significantly on the 5^th day. Rose Bengal staining showed on the first day after surgery and appeared most significantly on the 14th day. The biopsy showed: the layer of the cornea epithelium of the experimental eye increased. The squamous cell disappeared irregularly. The cells arranged disorderly. The surface of the conjuctiva was not smooth. And the goblet cell developed compensatory hyperplasia. Lacrimal glands showed no significant abnormal changes. CONCLUSION: Using suture method ectropion surgery to prepare rabbit dry eye model is stable, simple and effective, which is worth populating.