目的：观察光动力疗法治疗黄斑中心凹下脉络膜新生血管性疾病后的早期变化。 方法：经诊断有黄斑中心凹下脉络膜新生血管共10例13眼接受维替泊芬光动力疗法。在术前及术后3d分别行ETDRS视力、OCT及眼底检查，利用OCT自带软件分别测量层间厚度（Tf）、神经上皮厚度（Nf）、外层高反光带厚度（T）、视网膜下液（SF）等观测值。 结果：术后3d 10眼可见视网膜水肿，7眼可见视网膜下液增加，CNV病灶无明显改变。仅SF差别有统计学意义（P<0.05），且术后增加约133.38±184.94μm。ETDRS视力的字母数、Tf,Nf及T虽较术前增加，但差别无统计学意义。 结论：光动力疗法治疗脉络膜新生血管性病灶术后3d，OCT检查显示视网膜较前水肿，视网膜下液明显增加，这可能是患者术后早期色觉紊乱及视力下降的原因。

AIM: To study the early changes of choriodal neovascularization(CNV) after photodynamic therapy (PDT). METHODS: Ten cases（13 eyes） with subfoval CNV suffered PDT using visudyne. The changes of letters of ETDRS (early treatment for diabetic retinopathy study),optical coherence tomography (OCT) and fundus photography before and three days after PDT were compared. Using the software of OCT, the bilaminar foveal thickness (Tf),neuroretinal foveal thickness (Nf),outer high reflectivity band thickness (T) and subretinal fluid thickness (SF) were measured. RESULTS:Ten eyes were found retinal edema while 7 eyes were found increases of subretinal fluid three days after PDT. But CNV had no changes. Only the changes of SF had significant differences（P<0.05）, and increased about 133.38±184.94μm. The letters of ETDRS,Tf,Nf and T had increased but with no significant differences. CONCLUSION: Three days after PDT, OCT showed increases of retinal edema and subretinal fluid of CNV. This maybe the cause of the color vision chaos and decrease of visual acuity early after PDT.

Guangdong Provincial Science and Technology Project (No.2009B040704002)