目的：探讨膦甲酸钠滴眼液治疗上皮型单纯疱疹病毒性角膜炎（herpes simplex keratitis,HSK）的近中期疗效。 方法：选取2008-03/2009-12在钟祥市人民医院眼科门诊确诊的60例60眼上皮型HSK患者，将其随机分为对照组和试验组两组。对照组采用更昔洛韦滴眼液，8次/d；试验组采用膦甲酸钠滴眼液，6次/d，用药时间均为14d。观察治疗后3，7，10，14d的角膜溃疡面积、眼部症状体征评分，统计治愈率。随访2a，统计随访期间上皮型HSK的复发率。 结果:两组患者治疗前的一般情况、症状体征评分无显著差异（P>0.05）。与治疗前相比，治疗后两组患者的角膜溃疡面积、眼部症状体征评分均明显下降（P<0.05），但两组之间的角膜溃疡面积、眼部症状体征评分和治愈率均无明显差异（P>0.05）。随访2a期间，试验组和对照组患者的复发率分别是13%,27%，差异有显著性（P<0.05）。 结论:膦甲酸钠滴眼液在治疗上皮型HSK的近期疗效与更昔洛韦滴眼液相同，但中期复发率低于更昔洛韦滴眼液。

AIM: To investigate clinical effect of epithelial herpes simplex keratitis (HSK) treated by foscarnet sodium eye drops in the early and middle term.  METHODS:Totally 60 cases (60 eyes) with HSK at Zhongxiang Peoples Hospital from March 2008 to December 2009 were enrolled. All the patients were divided into control group and experimental group randomly. Control group patients were treated by ganciclovir eye drops, 8 times per day, while experimental group patients were treated by foscarnet sodium eye drops, 6 times per day. All patients were treated for 14 days and were followed up for 2 years. The medication outcome and recurrence rate were investigated.  RESULTS:There were no significant differences between control and experimental group in clinical characteristics of patients including age, gender, mean score of symptoms and signs before treatment (P>0.05). After therapy, both the corneal ulcer area and the score of symptoms and signs in control group patients and experimental group patients decreased significantly than those before treatment(P<0.05). But between two groups after treatment, the differences were not remarkable (P >0.05). In the 2 years follow-up, the recurrence rate in experimental group was significantly reduced compared with that in control group (P <0.05). CONCLUSION: Foscarnet sodium eye drops play a similar role in therapy of HSK with ganciclovir eyedrops in early stage, while may decrease the recurrence rate of HSK in the middle term."