包膜糖蛋白gB，gD是参与单纯疱疹病毒（herpes simplex virus,HSV）感染的基本结构蛋白, 具有重要的抗原表位, 参与病毒穿膜过程,介导了病毒的细胞间扩散,在病毒感染和宿主免疫过程中起着重要作用,其分子和功能特性的研究对HSV作用机制及预防的研究有着重要意义。近年来,该领域的研究取得一定进展，针对HSVgB，HSVgD的抗原表位已研究出相应疫苗，本文将对与单纯疱疹病毒性角膜炎（herpes simples keratitis,HSK）有关的糖蛋白gB，gD与疫苗的研究进展做一简要综述。

GlycoproteinB,D（gB， gD） are essential components for infection by herpes simplex virus-1 (HSV-1)，possess important epitope, participate in viral transmembrane process, mediate virus spreading between the cells, and play an important role in the process of host immune and viral infection.The study of their molecular and functional properties has important significance for research of herpes simplex keratitis(HSK) mechanism of action and preventation. In recent years, the research in HSVgB, HSVgD has certain progress, already developed vaccine specific to HSVgB, HSVgD epitope. Here,we reviewed the research progress in HSK related gB, gD and vaccine.

国家中药管理局资助项目(No．06-07LP41)；青海省科技厅资助项目(No．2007-N-129)